Welcome Comparative Effectiveness Research on Cancer in Texas (CERCIT)

CERCIT is a multidisciplinary consortium of investigators at the University of Texas Medical Branch (UTMB), MD Anderson Cancer Center, Rice University and the Texas Department of State Health Services Texas Cancer Registry. CERCIT is funded by the Cancer Prevention Research Institute of Texas (CPRIT).

CERCIT News

More Access to health care may lead to unnecessary mammograms

UTMB Newsroom, May 27, 2014

GALVESTON-Researchers have concluded that providing better access to health care may lead to the overuse of mammograms for women who regularly see a primary care physician and who have a limited life expectancy. The cautionary note from researchers at the University of Texas Medical Branch at Galveston is that screening women in this category could subject them “to greater risks of physical, emotional and economic suffering.”

Radiation therapy for cervical cancer increases risk for colorectal cancer

UTMB Newsroom, May 20, 2014

Texas researchers recommend new early colorectal cancer screening guidelines for young cervical cancer survivors. Researchers at the University of Texas Medical Branch at Galveston are the first to recommend that young women treated with radiation for cervical cancer should begin colorectal cancer screening earlier than traditionally recommended.

Increased risk for colorectal cancer following radiation therapy for cervical cancer

Medical News Today, April 22, 2014

Continuing coverage: Researchers at UTMB are the first to recommend that young women treated with radiation for cervical cancer should begin colorectal cancer screening earlier than traditionally recommended. The new CPRIT-funded study, which was recently posted online on the website for the journal Medical Oncology and featured Dr. Ana M. Rodriguez as lead author along with Dr. Yong-Fang Kuo and Dr. James S. Goodwin, reports a high level of incidence of secondary colorectal cancer diagnoses among survivors of cervical cancer who had been treated with radiation therapy. The news also appears in BioNews Texas.

More News

Publications

2013 CERCIT Publications
Benarroch-Gampel J, Sheffield KM, Boyd CA, Riall TS, Killewich LA. Population-based analysis of venous thromboembolic events following saphenous ablation. J Vasc Surg. In press In Press
Chavez-Macgregor M, Clarke CA, Lichtensztajn D, Hortobagyi GN, Giordano SH. Male breast cancer according to tumor subtype and race: A population based study. Cancer 119(9):1611-7, 5/2013. e-Pub 1/2013. PMID23341341
Du XL, Parikh RC, Lairson DR, Giordano SH, Cen P. Comparative effectiveness of platinum-based chemotherapy versus taxane and other regimens for ovarian cancer. Med Oncol. 2013 Mar;30(1):440. doi: 10.1007/s12032-012-0440-4. Epub 2013 Jan 10. PMID23307252
Giordano SH. Lumpectomy in Male Patients with Breast Cancer. Ann Surg Oncol 20(8):2460-1, 8/2013. e-Pub 5/2013. PMID23689936
Goodwin JS, Tan A, Jaramillo E, Kuo YF. Prostate-specific antigen testing in men aged 40-64 years: impact of publication of clinical trials. J Natl Cancer Inst. 2013 May 15;105(10):743-5. PMID: 23459245 PMID23459245
Parmar AD, Sheffield KM, Vargas GM, Han Y, Chao C, Riall TS. Quality of post-treatment surveillance of early stage breast cancer in Texas. Surgery. 2013 Aug; 154(2):214-25. PMID23889950
Sheffield KM, Han Y, Kuo YF, Riall TS, Goodwin JS. Potentially inappropriate screening colonoscopy in Medicare patients: variation by physician and geographic region. JAMA Intern Med. 2013 Apr 8;173(7):542-50. PMID: 23478992 PMID23478992
Sheffield KM, McAdams PS, Benarroch-Gampel J, Goodwin JS, Boyd CA, Zhang D, Riall TS. Overuse of preoperative cardiac stress testing in medicare patients undergoing elective noncardiac surgery. Ann Surg. 2013 Jan;257(1):73-80. PMID22964739
Singh A, Kuo YF, Goodwin JS. Many patients who undergo surgery for colorectal cancer receive surveillance colonoscopies earlier than recommended by guidelines. Clin Gastroenterol Hepatol. 2013 PMID22902760
Tan A, Kuo Y, Goodwin JS. Predicting life expectancy for community dwelling older adults using Medicare claims data. Am J Epidemiol 2013; doi: 10.1093/aje/kwt054 not available
Tan A, Kuo YF, Elting LS, Goodwin JS. Refining physician quality indicators for screening mammography in older women: Distinguishing appropriate use from overuse. J Am Geriatri Soc 2013; 61(3):380-7. PMCID: PMC3602404 PMID3602404
Vargas GM, Sheffield KM, Parmar AD, Han Y, Brown KM, Riall TS. Physician follow-up and observation of guidelines in the post treatment surveillance of colorectal cancer. Surgery 2013 Aug; 154(2):244-55. PMID23889952
Walker GV, Giordano SH, Williams M, Jiang J, Niu J, MacKinnon J, Anderson P, Wohler B, Sinclair AH, Boscoe FP, Schymura MJ, Buchholz TA, Smith BD. Muddy water? Variation in reporting receipt of breast cancer radiation therapy by population-based tumor registries. Int J Radiation Oncol Biol Phys. 2013; 86(4): 686-693. PMID23773392
Zimmermann CJ, Sheffield KM, Duncan CB, Han Y, Cooksley CD, Townsend CM Jr, Riall TS. Time trends and geographic variation in use of minimally invasive breast biopsy. J Am Coll Surg 216: 814-824, 2013. PMID 23376029, PMCID pending. PMID23376029
2012 CERCIT Publications
Albert JM, Liu DD, Shen Y, Pan IW, Shih YC, Hoffman KE, Buchholz TA, Giordano SH, Smith BD. Nomogram to predict the benefit of radiation for older patients with breast cancer treated with conservative surgery. J Clin Oncol. 2012 Aug 10;30(23):2837-43. Epub 2012 Jun 25. PMID22734034
Albert JM, Pan IW, Shih YC, Jiang J, Buchholz TA, Giordano SH, Smith BD. Effectiveness of radiation for prevention of mastectomy in older breast cancer patients treated with conservative surgery. Cancer. 2012 Aug 13. doi: 10.1002/cncr.27457. [Epub ahead of print] PMID22890779
Barcenas CH, Zhang N, Zhao H, Duan Z, Buchholz TA, Hortobagyi GN, Giordano SH. Anthracycline regimen adherence in older patients with early breast cancer. Oncologist. 2012;17(3):303-11. Epub 2012 Feb 27. PMID22371383
Benarroch-Gampel J, Lairson DR, Boyd CA, Sheffield KM, Ho V, Riall TS. Cost-effectiveness analysis of cholecystectomy during Roux-en-Y gastric bypass for morbid obesity. Surgery. 2012 Sep;152(3):363-75. PMID22938897
Benarroch-Gampel J, Sheffield KM, Duncan CB, Brown KM, Han Y, Townsend CM Jr, Riall TS. Preoperative laboratory testing in patients undergoing elective, low-risk ambulatory surgery. Ann Surg. 2012 Sep;256(3):518-28. PMID22868362
Benarroch-Gampel J, Sheffield KM, Lin YL, Kuo YF, Goodwin JS, Riall TS. Colonoscopist and primary care physician supply and disparities in colorectal cancer screening. Health Serv Res. 2012 Jun;47(3 Pt 1):1137-57. doi: 10.1111/j.1475-6773.2011.01355.x. Epub 2011 Dec 8. PMID22150580
Boyd CA, Benarroch-Gampel J, Sheffield KM, Cooksley CD, Riall TS. 415 patients with adenosquamous carcinoma of the pancreas: a population-based analysis of prognosis and survival. J Surg Res. 2012 May 1;174(1):12-9. Epub 2011 Jul 7. PMID21816433
Boyd CA, Benarroch-Gampel J, Kilic G, Kruse EJ, Weber SM, Riall TS. Pancreatic neoplasms in pregnancy: diagnosis, complications, and management. J Gastrointest Surg. 2012 May;16(5):1064-71. Epub 2011 Dec 9. PMID22160782
Boyd CA, Benarroch-Gampel J, Sheffield KM, Han Y, Kuo YF, Riall TS. The effect of depression on stage at diagnosis, treatment, and survival in pancreatic adenocarcinoma. Surgery. 2012 Sep;152(3):403-13. PMID22938900
Boyd CA, Branch DW, Sheffield KM, Han Y, Kuo YF, Goodwin JS, Riall TS. Hospital and medical care days in pancreatic cancer. Ann Surg Oncol. 2012 Aug;19(8):2435-42. Epub 2012 Mar 27. PMID22451235
Chavez-Macgregor M, Brown E, Lei X, Litton J, Meric-Bernstram F, Mettendorf E, Hernandez L, Valero V, Hortobagyi GN, Gonzalez-Angulo AM. Bisphosphonates and pathologic complete response to taxane- and anthracycline-based neoadjuvant chemotherapy in patients with breast cancer. Cancer. 2012 Jan 15;118(2):326-32. doi: 10.1002/cncr.26144. Epub 2011 May 16. PMID21590688
Cheng L, Swartz MD, Zhao H, Kapadia AS, Lai D, Rowan PJ, Buchholz TA, Giordano SH. Hazard of recurrence among women after primary breast cancer treatment--a 10-year follow-up using data from SEER-Medicare. Cancer Epidemiol Biomarkers Prev. 2012 May;21(5):800-9. Epub 2012 Mar 16. PMID22426147
Giordano SH, Lin YL, Kuo YF, Hortobagyi GN, Goodwin JS. Decline in the use of anthracyclines for breast cancer. J Clin Oncol. 2012 Jun 20;30(18):2232-9. Epub 2012 May 21. PMID22614988
Gokula M, Holmes HM. Tools to reduce polypharmacy. Clin Geriatr Med. 2012 May;28(2):323-41. PMID22500546
Gonzalez-Angulo AM, Chen H, Karuturi MS, Chavez-Macgregor M, Tsavachidis S, Meric-Bernstam F, Do KA, Hortobagyi GN, Thompson PA, Mills GB, Bondy ML, Blumenschein GR Jr. Frequency of mesenchymal-epithelial transition factor gene (MET) and the catalytic subunit of phosphoinositide-3-kinase (PIK3CA) copy number elevation and correlation with outcome in patients with early stage breast cancer. Cancer. 2012 Jun 26. doi: 10.1002/cncr.27608. [Epub ahead of print] PMID22736407
Howrey BT, Kuo YF, Lin Y, Goodwin JS. The impact of PSA screening on prostate cancer mortality and overdiagnosis of prostate cancer in the United States. J Gerontol Series A: Bio Sci and Med Sci. 2012 May 4. [Epub ahead of print]. PMID22562961
Hurria A, Browner IS, Cohen HJ, Denlinger CS, deShazo M, Extermann M, Ganti AK, Holland JC, Holmes HM, Karlekar MB, Keating NL, McKoy J, Medeiros BC, Mrozek E, O'Connor T, Petersdorf SH, Rugo HS, Silliman RA, Tew WP, Walter LC, Weir AB 3rd, Wildes T. Senior adult oncology. J Natl Compr Canc Netw. 2012 Feb;10(2):162-209. PMID22308515
Lynch SP, Lei X, Chavez-Macgregor M, Hsu L, Meric-Bernstam F, Buchholz TA, Zhang A, Hortobagyi GN, Valero V, Gonzalez-Angulo AM. Multifocality and multicentricity in breast cancer and survival outcomes. Ann Oncol. 2012 Jul 9. [Epub ahead of print]. PMID22776706
Morris GS, des Bordes JKA, Holmes HM, Giralt S. Frailty and stem cell transplantation in the older patient with cancer J Geri Onc. 2012 Jul; 3(3):273-78. No PMID listed
Raghav KP, Wang W, Liu S, Chavez-MacGregor M, Meng X, Hortobagyi GN, Mills GB, Meric-Bernstam F, Blumenschein GR Jr, Gonzalez-Angulo AM. cMET and phospho-cMET protein levels in breast cancers and survival outcomes. Clin Cancer Res. 2012 Apr 15;18(8):2269-77. Epub 2012 Feb 28. PMID22374333
Rojas Y, Warneke CL, Dhamne CA, Tsao K, Nuchtern JG, Lally KP, Vasudevan SA, Hayes-Jordan AA, Cass DL, Herzog CE, Hicks MJ, Kim ES, Austin MT. Primary malignant pancreatic neoplasms in children and adolescents: a 20 year experience. J Pediatr Surg. 2012 Dec;47(12):2199-204. PMID23217876
Sheffield KM, Crowell KT, Lin YL, Djukom C, Goodwin JS, Riall TS. Surveillance of pancreatic cancer patients after surgical resection. Ann Surg Oncol. 2012 May;19(5):1670-7. Epub 2011 Dec 6. PMID22143577
Singal A, Kuo YF, Lin YL, Riall TS, Goodwin JS. Primary care physicians and disparities in colorectal cancer. Health Serv Res. 2012 Jul; doi: 10.1111/j.1475-6773.2012.01433.x. [Epub ahead of print]. PMID22716124
Singh A, Kuo YF, Goodwin JS. Surveillance Colonoscopy at Earlier than Recommended Guidelines Among Colorectal Cancer Survivors. Clin Gastro & Hep, in press. PMID22902760
Smith GL, Xu Y, Buchholz TA, Giordano SH, Jiang J, Shih YC, Smith BD. Association between treatment with brachytherapy vs whole-breast irradiation and subsequent mastectomy, complications, and survival among older women with invasive breast cancer. JAMA. 2012 May 2;307(17):1827-37. PMID22550197
Tan A, Kuo YF, Goodwin JS. Integrating age and comorbidity to assess screening mammography utilization. Am J Prev Med. 2012 Mar; 42(3):229-34. PMID22341159
2011 CERCIT Publications
Baillargeon J, Kuo YF, Lin Y, Raji MA, Singh A, Goodwin JS. Effect of Mental Disorders on Diagnosis, Treatment, and Survival of Older Patients with Colon Cancer. J Am Geriatr Soc. 2011 Jul; 59(7):1268-73. PMID21732924
Benarroch-Gampel J, Boyd CA, Sheffield KM, Townsend CM Jr, Riall TS. Overuse of CT in patients with complicated gallstone disease. J Am Coll Surg. 2011 Oct;213(4):524-30. Epub 2011 Aug 20. PMID21862355
Chavez-MacGregor M, Zhao H, Fang S, Srokowski TP, Hortobagyi GN, Giordano SH. Complications associated with erythropoietin-stimulating agents in patients with metastatic breast cancer: a Surveillance, Epidemiology, and End Results-Medicare study. Cancer. 2011 Aug 15;117(16):3641-9. doi: 10.1002/cncr.25972. Epub 2011 Feb 24. PMID21656514
Chavez-MacGregor M, Zhao H, Kroll M, Fang S, Zhang N, Hortobagyi GN, Buchholz TA, Shih YC, Giordano SH. Risk factors and incidence of thromboembolic events (TEEs) in older men and women with breast cancer. Ann Oncol. 2011 Nov;22(11):2394-402. Epub 2011 Mar 10. PMID21393379
Cutchin MP, Eschbach, K, Mair CA, Ju H, Goodwin JS. The socio-spatial neighborhood estimation method: An approach to operationalizing the neighborhood concept. Health & Place. 2011, Sep;17(5):1113-21. Epub 2011 Jun 7. PMID21684793
Goodwin JS, Singh A, Reddy N, Riall TS, Kuo YF. Overuse of screening colonoscopy in the Medicare population. Arch Intern Med. 2011 Aug 8;171(15):1335-43. Epub 2011 May 9. PMID21555653
Raghav KP, Hernandez-Aya LF, Lei X, Chavez-Macgregor M, Meric-Bernstam F, Buchholz TA, Sahin A, Do KA, Hortobagyi GN, Gonzalez-Angulo AM. Impact of low estrogen/progesterone receptor expression on survival outcomes in breast cancers previously classified as triple negative breast cancers. Cancer. 2012 Mar 15;118(6):1498-506. doi: 10.1002/cncr.26431. Epub 2011 Aug 11. PMID21837669
Reyes-Ortiz CA, Goodwin JS, Zhang DD, Freeman JL. Socioeconomic status and chemotherapy use for melanoma in older people. Canadian J on Aging. 2011; 30(1):143-153. PMID21356154
Riall TS, Sheffield KM, Kuo YF, Townsend CM Jr, Goodwin JS. Resection benefits older adults with locoregional pancreatic cancer despite greater short-term morbidity and mortality. J Am Geriatr Soc. 2011 Apr;59(4):647-54. doi: 10.1111/j.1532-5415.2011.03353.x. Epub 2011 Mar 31. PMID21453378
Sheffield KM, Boyd CA, Benarroch-Gampel J, Kuo YF, Cooksley CD, Riall TS. End-of-life care in Medicare beneficiaries dying with pancreatic cancer. Cancer. 2011 Nov 1;117(21):5003-12. doi: 10.1002/cncr.26115. Epub 2011 Apr 14. PMID21495020
Singh A, Kuo YF, Riall TS, Raju GS, Goodwin JS. Predictors of colorectal cancer following a negative colonoscopy in the Medicare population. Dig Dis Sci. 2011 Nov;56(11):3122-8. Epub 2011 Jun 17. PMID21681506
Smith BD, Pan IW, Shih YC, Smith GL, Harris JR, Punglia R, Pierce LJ, Jagsi R, Hayman JA, Giordano SH, Buchholz TA. Adoption of intensity-modulated radiation therapy for breast cancer in the United States. J Natl Cancer Inst. 2011 May 18;103(10):798-809. Epub 2011 Apr 27. PMID21525437
Theriault RL, Litton JK, Mittendorf EA, Chen H, Meric-Bernstam F, Chavez-Macgregor M, Morrow PK, Woodward WA, Sahin A, Hortobagyi GN, Gonzalez-Angulo AM. Age and survival estimates in patients who have node-negative T1ab breast cancer by breast cancer subtype. Clin Breast Cancer. 2011 Oct;11(5):325-31. Epub 2011 Jul 20. PMID21764391

 

Videos

CERCIT Workshop August 2014
Fun with Medicare Part D Data presented by James S. Goodwin, MD

CERCIT Workshop August 2014
Shared Decision Making in Cancer Care presented by Nina Tamirisa, MD

CERCIT Workshop June 2014
The use of surgery in the elderly for management of metastatic epidural spinal cord compression
presented by Justin E. Bird, MD

CERCIT Workshop June 2014
Population-based assessment of breast reconstruction
presented by Ben Smith, MD

Data & Reports

Fact Sheets

Prostate Cancer [PDF]: Prostate Specific Antigen (PSA) Testing in Men Aged 65 & Older

Mammography [PDF]: Mammography in Women Aged 65 & Older

Colonoscopy [PDF]: Colonoscopy in Adults Aged 65 & Older

Reports and Special Publications

Hispanic Cancer Report [PDF]: From A quarterly publication of the Texas Public Health Association (TPHA) Supplement, Fall 2013, A Comprehensive Report on Cancer among Hispanics in Texas.

CERCIT Featured in the Texas Public Health Journal Summer 2013
Using research to keep Texans informed about cancer care – that is at the heart of CERCIT (Comparative Effectiveness Research on Cancer in Texas). A description of this project and selected articles from its four research areas are featured in the Spring 2013 issue of the Texas Public Health Journal, a quarterly publication of the Texas Public Health Association (pages 22-55):

Just how much does cancer cost in Texas? [PDF] Texas Public Health Journal, Vol 63, Issue 4, Fall 2011. Findings are reported in the Cost of Cancer in Texas, 2005 [PDF] published by the Texas Cancer Council.

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Manuscript Acknowledgement: This work was supported [in part] by the Comparative Effectiveness Research on Cancer in Texas (CERCIT) Grant #RP101207, funded by The Cancer Prevention Research Institute of Texas (CPRIT).